Broncos at Patriots: aka Jesus versus Satan, the Sequel. Even though he won last time, I'm still putting my money on Dr. Evil and his Yankee henchmen. Hey, I tend to root for the bad guy all the time - just ask Chef Spouse. Pats.
Texans at Ravens: I know just last week I realized I should've stuck with my former Team of Destiny, but unless they manage to bring all 70,000 Texans fans with them to M&T Bank Stadium - and I think the Ravens fans might have something to say about that - I think they're in trouble this week. Ravens.
Giants at Packers: The Giants are the popular upset pick in my office football pool (no cash at stake, just smack talking/bragging rights). I'm thinking "rested" not "rusty" though, and I'm going with the Packers.
Saints at 49ers: This is my upset pick. I'm going with the 49ers. The Saints are mortal away from the Superdome and their fan base. If offense wins games while defense wins championships...and if all else fails, the 49ers have their secret weapon, Chef Spouse's boy David Akers. Who can onside kick like nobody's business and, apparently, throw TDs in a pinch.